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Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

The two presenilin‐1 (PS1) and presenilin‐2 (PS2) homologs are the catalytic core of the γ‐secretase complex, which has a major role in cell fate decision and Alzheimer's disease (AD) progression. Understanding the precise contribution of PS1‐ and PS2‐dependent γ‐secretases to the production of...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Stanga, Serena, Vrancx, Céline, Tasiaux, Bernadette, Marinangeli, Claudia, Karlström, Helena, Kienlen‐Campard, Pascal
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783875/
https://ncbi.nlm.nih.gov/pubmed/28994238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13364
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