CCR5 Inhibitors and HIV-1 Infection

Por Latinovic, Olga S., Reitz, Marvin, Heredia, Alonso
Publicado no J AIDS HIV Treat (2019)

Pharmacotherapy of HIV-1 Infection: Focus on CCR5 Antagonist Maraviroc

Por Latinovic, Olga, Kuruppu, Janaki, Davis, Charles, Le, Nhut, Heredia, Alonso
Publicado em 2009

A novel small-molecule inhibitor of HIV-1 entry

Por Heredia, Alonso, Latinovic, Olga S, Barbault, Florent, de Leeuw, Erik PH
Publicado no Drug Des Devel Ther (2015)

Use of Humanized Mouse Models for Studying HIV-1 Infection, Pathogenesis and Persistence

Por Weichseldorfer, Matthew, Heredia, Alonso, Reitz, Marvin, Bryant, Joseph L., Latinovic, Olga S.
Publicado no J AIDS HIV Treat (2020)

Binding of fusion protein FLSC IgG1 to CCR5 is enhanced by CCR5 antagonist Maraviroc

Por Latinovic, Olga, Schneider, Kate, Szmacinski, Henryk, Lakowicz, Joseph R., Heredia, Alonso, Redfield, Robert R.
Publicado no Antiviral Res (2014)

An Alteration of Human Immunodeficiency Virus gp41 Leads to Reduced CCR5 Dependence and CD4 Independence

Por Taylor, Brian M., Foulke, J. Scott, Flinko, Robin, Heredia, Alonso, DeVico, Anthony, Reitz, Marvin
Publicado em 2008

Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1

Por Heredia, Alonso, Latinovic, Olga, Gallo, Robert C., Melikyan, Gregory, Reitz, Marv, Le, Nhut, Redfield, Robert R.
Publicado em 2008

Synergistic Inhibition of R5 HIV-1 by Maraviroc and CCR5 Antibody HGS004 in Primary Cells: Implications for Treatment and Prevention

Por LATINOVIC, OLGA, LE, NHUT, REITZ, MARVIN, PAL, RANAJIT, DEVICO, ANTHONY, FOULKE, JAMES S., REDFIELD, ROBERT R., HEREDIA, ALONSO
Publicado em 2011

CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells

Por Latinovic, Olga, Reitz, Marvin, Le, Nhut M., Foulke, James S., Fätkenheuer, Gerd, Lehmann, Clara, Redfield, Robert R., Heredia, Alonso
Publicado em 2011

Induction of G(1) cycle arrest in T lymphocytes results in increased extracellular levels of β-chemokines: A strategy to inhibit R5 HIV-1

Por Heredia, Alonso, Davis, Charles, Amoroso, Anthony, Dominique, Joyelle K., Le, Nhut, Klingebiel, Erin, Reardon, Elise, Zella, Davide, Redfield, Robert R.
Publicado em 2003

Indirubin 3′-Monoxime, from a Chinese Traditional Herbal Formula, Suppresses Viremia in Humanized Mice Infected with Multidrug-Resistant HIV

Por Heredia, Alonso, Natesan, Senthilkumar, Le, Nhut M., Medina-Moreno, Sandra, Zapata, Juan C., Reitz, Marvin, Bryant, Joseph, Redfield, Robert R.
Publicado em 2014

Enzymatic glycosylation of triazole-linked GlcNAc/Glc-peptides. Synthesis, stability, and anti-HIV activity of triazole-linked HIV-1 gp41 glycopeptide C34

Por Huang, Wei, Groothuys, Stan, Heredia, Alonso, Kuijpers, Brian H.M., Rutjes, Floris P.J.T., van Delft, Floris L., Wang, Lai-Xi
Publicado em 2009

Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1

Por Heredia, Alonso, Davis, Charles E., Reitz, Marvin S., Le, Nhut M., Wainberg, Mark A., Foulke, James S., Wang, Lai-Xi, Redfield, Robert R.
Publicado em 2013

Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice

Por Medina-Moreno, Sandra, Dowling, Thomas C., Zapata, Juan C., Le, Nhut M., Sausville, Edward, Bryant, Joseph, Redfield, Robert R., Heredia, Alonso
Publicado no PLoS One (2017)

Rapamycin Reduces CCR5 Density Levels on CD4 T Cells, and This Effect Results in Potentiation of Enfuvirtide (T-20) against R5 Strains of Human Immunodeficiency Virus Type 1 In Vit...

Por Heredia, Alonso, Gilliam, Bruce, Latinovic, Olga, Le, Nhut, Bamba, Douty, DeVico, Anthony, Melikyan, Gregory B., Gallo, Robert C., Redfield, Robert R.
Publicado em 2007

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

Por Heredia, Alonso, Le, Nhut, Gartenhaus, Ronald B., Sausville, Edward, Medina-Moreno, Sandra, Zapata, Juan C., Davis, Charles, Gallo, Robert C., Redfield, Robert R.
Publicado no Proc Natl Acad Sci U S A (2015)

Targeting Host Nucleotide Biosynthesis with Resveratrol Inhibits Emtricitabine (FTC)-resistant HIV-1

Por Heredia, Alonso, Davis, Charles, Amin, Mohammed N, Le, Nhut M, Wainberg, Mark A, Oliveira, Maureen, Deeks, Steven G, Wang, Lai-Xi, Redfield, Robert R
Publicado no AIDS (2014)

Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice

Por Heredia, Alonso, Hassounah, Said, Medina-Moreno, Sandra, Zapata, Juan C., Le, Nhut M., Han, Yingshan, Foulke, James S., Davis, Charles, Bryant, Joseph, Redfield, Robert R., Wainberg, Mark A.
Publicado no J Antimicrob Chemother (2017)

Disparate Effects of Cytotoxic Chemotherapy on the Antiviral Activity of Antiretroviral Therapy: Implications for Treatments of HIV-Infected Cancer Patients

Por Medina-Moreno, Sandra, Zapata, Juan C, Cottrell, Mackenzie L., Le, Nhut M, Tao, Sijia, Bryant, Joseph, Sausville, Edward, Schinazi, Raymond F, Kashuba, Angela DM, Redfield, Robert R, Heredia, Alonso
Publicado no Antivir Ther (2019)

Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors

Por Pinto, Daniel O., DeMarino, Catherine, Vo, Thy T., Cowen, Maria, Kim, Yuriy, Pleet, Michelle L., Barclay, Robert A., Noren Hooten, Nicole, Evans, Michele K., Heredia, Alonso, Batrakova, Elena V., Iordanskiy, Sergey, Kashanchi, Fatah
Publicado no Viruses (2020)