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Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1

Vicriviroc (VCV) is a chemokine (C-C motif) receptor 5 (CCR5) antagonist with potent anti-HIV activity that currently is being evaluated in phase III clinical trials. In the present study, donor CCR5 density (CCR5 receptors/CD4 lymphocytes) inversely correlated with VCV antiviral activity (Spearman&...

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Main Authors: Heredia, Alonso, Latinovic, Olga, Gallo, Robert C., Melikyan, Gregory, Reitz, Marv, Le, Nhut, Redfield, Robert R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629281/
https://ncbi.nlm.nih.gov/pubmed/19075241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810843106
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