CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells

R5 HIV-1 strains resistant to the CCR5 antagonist Maraviroc (MVC) can use drug-bound CCR5. We demonstrate that MVC-resistant HIV-1 exhibits delayed kinetics of coreceptor engagement and fusion during drug-bound versus free CCR5 infection of cell lines. Antibodies directed against the second extracel...

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Bibliographic Details
Main Authors: Latinovic, Olga, Reitz, Marvin, Le, Nhut M., Foulke, James S., Fätkenheuer, Gerd, Lehmann, Clara, Redfield, Robert R., Heredia, Alonso
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039059/
https://ncbi.nlm.nih.gov/pubmed/21232779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.029
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