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Synergistic Inhibition of R5 HIV-1 by Maraviroc and CCR5 Antibody HGS004 in Primary Cells: Implications for Treatment and Prevention
CCR5 blockers inhibit CCR5-tropic (R5) HIV-1, including strains resistant to other antiretrovirals. We demonstrate that the CCR5 antibody HGS004 and the CCR5 antagonist Maraviroc have potent antiviral synergy against R5 HIV-1, translating into dose reductions of >10-fold for Maraviroc and >150...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748726/ https://ncbi.nlm.nih.gov/pubmed/21505306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283471edb |
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