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Synergistic Inhibition of R5 HIV-1 by Maraviroc and CCR5 Antibody HGS004 in Primary Cells: Implications for Treatment and Prevention

CCR5 blockers inhibit CCR5-tropic (R5) HIV-1, including strains resistant to other antiretrovirals. We demonstrate that the CCR5 antibody HGS004 and the CCR5 antagonist Maraviroc have potent antiviral synergy against R5 HIV-1, translating into dose reductions of >10-fold for Maraviroc and >150...

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書誌詳細
主要な著者: LATINOVIC, OLGA, LE, NHUT, REITZ, MARVIN, PAL, RANAJIT, DEVICO, ANTHONY, FOULKE, JAMES S., REDFIELD, ROBERT R., HEREDIA, ALONSO
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748726/
https://ncbi.nlm.nih.gov/pubmed/21505306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283471edb
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