Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1

Background. Targeting host-cell pathways to increase the potency of nucleoside/nucleotide analog reverse transcriptase inhibitors (NRTIs) is an important strategy for clinical investigation. Resveratrol is a natural product that inhibits cellular ribonucleotide reductase, prolonging the S phase of t...

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Detalhes bibliográficos
Main Authors: Heredia, Alonso, Davis, Charles E., Reitz, Marvin S., Le, Nhut M., Wainberg, Mark A., Foulke, James S., Wang, Lai-Xi, Redfield, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836462/
https://ncbi.nlm.nih.gov/pubmed/23922365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit395
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