Targeting Host Nucleotide Biosynthesis with Resveratrol Inhibits Emtricitabine (FTC)-resistant HIV-1

OBJECTIVE: The M184V mutation in the HIV-1 reverse transcriptase (RT) gene is frequent (> 50 %) in patients, both in resource-rich and resource-limited countries, conferring high-level resistance (> 100-fold) to the cytosine analog RT inhibitors 3TC and FTC. The RT enzyme of M184V HIV-1 mutant...

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Publicat a:AIDS
Autors principals: Heredia, Alonso, Davis, Charles, Amin, Mohammed N, Le, Nhut M, Wainberg, Mark A, Oliveira, Maureen, Deeks, Steven G, Wang, Lai-Xi, Redfield, Robert R
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469130/
https://ncbi.nlm.nih.gov/pubmed/24326355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000168
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