Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas

Por Nathenson, Michael J., Conley, Anthony P., Sausville, Edward
Publicado no Oncologist (2017)

Unique amplification of BCR-ABL1 gene fusion in a case of T-cell acute lymphoblastic leukemia

Por Koka, Rima, Bade, Najeebah A., Sausville, Edward A., Ning, Yi, Zou, Ying
Publicado no Mol Cytogenet (2017)

Interactive Effects of HDAC Inhibitors and TRAIL on Apoptosis Are Associated with Changes in Mitochondrial Functions and Expressions of Cell Cycle Regulatory Genes in Multiple Myel...

Por Fandy, Tamer E, Shankar, Sharmila, Ross, Douglas D, Sausville, Edward, Srivastava, Rakesh K
Publicado em 2005

Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery

Por Borgman, Mark P., Aras, Omer, Geyser-Stoops, Sandra, Sausville, Edward A., Ghandehari, Hamidreza
Publicado em 2009

Targetable HPMA Copolymer–Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy

Por Borgman, Mark P., Ray, Abhijit, Kolhatkar, Rohit B., Sausville, Edward A., Burger, Angelika M., Ghandehari, Hamidreza
Publicado em 2009

Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate

Por Duncan, Ruth, Sat-Klopsch, Yee-Nee, Burger, Angelika M., Bibby, Michael C., Fiebig, Heinz H., Sausville, Edward A.
Publicado em 2013

Clinical Pharmacokinetics and Exposure-Toxicity Relationship of a Folate-Vinca Alkaloid Conjugate EC145 in Cancer Patients

Por Li, Jing, Sausville, Edward A., Klein, Patrick J., Morgenstern, David, Leamon, Christopher P., Messmann, Richard A., LoRusso, Patricia
Publicado em 2009

Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor

Por Sodhi, Akrit, Montaner, Silvia, Patel, Vyomesh, Gómez-Román, José Javier, Li, Yi, Sausville, Edward A., Sawai, Earl T., Gutkind, J. Silvio
Publicado em 2004

Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2

Por LoRusso, Patricia, Venkatakrishnan, Karthik, Chiorean, E. Gabriela, Noe, Dennis, Wu, Jing-Tao, Sankoh, Serap, Corvez, Maria, Sausville, Edward A.
Publicado em 2013

A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

Por Pidugu, Lakshmi Swarna Mukhi, Mbimba, J.C. Emmanuel, Ahmad, Muqeet, Pozharski, Edwin, Sausville, Edward A., Emadi, Ashkan, Toth, Eric A.
Publicado no BMC Struct Biol (2016)

Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice

Por Medina-Moreno, Sandra, Dowling, Thomas C., Zapata, Juan C., Le, Nhut M., Sausville, Edward, Bryant, Joseph, Redfield, Robert R., Heredia, Alonso
Publicado no PLoS One (2017)

Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome

Por Gojo, Ivana, Perl, Alexander, Luger, Selina, Baer, Maria R., Norsworthy, Kelly J., Bauer, Kenneth S., Tidwell, Michael, Fleckinger, Stephanie, Carroll, Martin, Sausville, Edward A.
Publicado em 2013

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

Por Heredia, Alonso, Le, Nhut, Gartenhaus, Ronald B., Sausville, Edward, Medina-Moreno, Sandra, Zapata, Juan C., Davis, Charles, Gallo, Robert C., Redfield, Robert R.
Publicado no Proc Natl Acad Sci U S A (2015)

Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

Por Schwartz, Gary K., Dickson, Mark A., LoRusso, Patricia M., Sausville, Edward A., Maekawa, Yoshimi, Watanabe, Yasuo, Kashima, Naomi, Nakashima, Daisuke, Akinaga, Shiro
Publicado no Cancer Sci (2016)

Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia ce...

Por Carter-Cooper, Brandon A., Fletcher, Steven, Ferraris, Dana, Choi, Eun Yong, Kronfli, Dahlia, Dash, Smaraki, Truong, Phuc, Sausville, Edward A., Lapidus, Rena G., Emadi, Ashkan
Publicado no Bioorg Med Chem Lett (2016)

A Phase I Trial of UCN-01 and Prednisone in Patients With Refractory Solid Tumors and Lymphomas

Por Kummar, Shivaani, Gutierrez, Martin E., Gardner, Erin R., Figg, William, Melillo, Giovanni, Dancey, Janet, Sausville, Edward A., Conley, Barbara A., Murgo, Anthony J., Doroshow, James H.
Publicado em 2009

SAFETY, EFFICACY, PHARMACOKINETICS AND PHARMACODYNAMICS OF THE COMBINATION OF SORAFENIB AND TANESPIMYCIN

Por Vaishampayan, Ulka N., Burger, Angelika M., Sausville, Edward A., Heilbrun, Lance K., Li, Jing, Horiba, Naomi, Egorin, Merrill J., Ivy, Percy, Pacey, Simon, Lorusso, Patricia M.
Publicado em 2010

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

Por Sausville, Edward, LoRusso, Patricia, Carducci, Michael, Carter, Judith, Quinn, Mary F., Malburg, Lisa, Azad, Nilofer, Cosgrove, David, Knight, Richard, Barker, Peter, Zabludoff, Sonya, Agbo, Felix, Oakes, Patricia, Senderowicz, Adrian
Publicado no Cancer Chemother Pharmacol (2014)

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

Por Chandra, Joya, Tracy, Jeannette, Loegering, David, Flatten, Karen, Verstovsek, Srdan, Beran, Miloslav, Gorre, Mercedes, Estrov, Zeev, Donato, Nicholas, Talpaz, Moshe, Sawyers, Charles, Bhalla, Kapil, Karp, Judith, Sausville, Edward, Kaufmann, Scott H.
Publicado em 2006

A phase I/II study of carfilzomib 2–10-min infusion in patients with advanced solid tumors

Por Papadopoulos, Kyriakos P., Burris, Howard A., Gordon, Michael, Lee, Peter, Sausville, Edward A., Rosen, Peter J., Patnaik, Amita, Cutler, Richard E., Wang, Zhengping, Lee, Susan, Jones, Suzanne F., Infante, Jeffery R.
Publicado em 2013