Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2

Introduction This phase 1 study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, cerebrospinal fluid (CSF) distribution, and preliminary clinical activity of the receptor tyrosine kinase inhibitor TAK-285. Methods Patients with advanced, histologically confirmed solid tumors and East...

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Detalhes bibliográficos
Main Authors: LoRusso, Patricia, Venkatakrishnan, Karthik, Chiorean, E. Gabriela, Noe, Dennis, Wu, Jing-Tao, Sankoh, Serap, Corvez, Maria, Sausville, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Phase I Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913854/
https://ncbi.nlm.nih.gov/pubmed/23817974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-9988-x
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