Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

HIV necessitates host factors for successful completion of its life cycle. Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1 and mTORC2. Rapamycin is an allosteric inhibitor of mTOR that selectively inhibits mTORC1. Rapamycin interferes with...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Heredia, Alonso, Le, Nhut, Gartenhaus, Ronald B., Sausville, Edward, Medina-Moreno, Sandra, Zapata, Juan C., Davis, Charles, Gallo, Robert C., Redfield, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522811/
https://ncbi.nlm.nih.gov/pubmed/26170311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511144112
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