Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells

The synthesis, characterization and antileukemic activity of rationally designed amino dimeric naphthoquinone (BiQ) possessing aziridine as alkylating moiety is described. Bis-aziridinyl BiQ decreased proliferation of acute myeloid leukemia (AML) cell lines and primary cells from patients, and exhib...

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Опубликовано в: :Bioorg Med Chem Lett
Главные авторы: Carter-Cooper, Brandon A., Fletcher, Steven, Ferraris, Dana, Choi, Eun Yong, Kronfli, Dahlia, Dash, Smaraki, Truong, Phuc, Sausville, Edward A., Lapidus, Rena G., Emadi, Ashkan
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654471/
https://ncbi.nlm.nih.gov/pubmed/27890379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.045
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