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Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells

The synthesis, characterization and antileukemic activity of rationally designed amino dimeric naphthoquinone (BiQ) possessing aziridine as alkylating moiety is described. Bis-aziridinyl BiQ decreased proliferation of acute myeloid leukemia (AML) cell lines and primary cells from patients, and exhib...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Carter-Cooper, Brandon A., Fletcher, Steven, Ferraris, Dana, Choi, Eun Yong, Kronfli, Dahlia, Dash, Smaraki, Truong, Phuc, Sausville, Edward A., Lapidus, Rena G., Emadi, Ashkan
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654471/
https://ncbi.nlm.nih.gov/pubmed/27890379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.045
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