A Systems Biology Approach to Personalizing Therapeutic Combinations

per Kwong, Lawrence N, Heffernan, Timothy P, Chin, Lynda
Publicat 2013

Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G(1 )checkpoint function

per Simpson, Dennis A, Livanos, Elizabeth, Heffernan, Timothy P, Kaufmann, William K
Publicat 2005

ATR-Chk1 pathway inhibition promotes apoptosis after UV in primary human keratinocytes: potential basis for caffeine’s UV protective effects

per Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul
Publicat 2009

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research

per Inoue, Akira, Deem, Angela K., Kopetz, Scott, Heffernan, Timothy P., Draetta, Giulio F., Carugo, Alessandro
Publicat a Cancers (Basel) (2019)

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

per Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., Heinloth, Alexandra N., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K.
Publicat 2002

Cdc7/Dbf4 and the Human S Checkpoint Response to UVC

per Heffernan, Timothy P., Ünsal-Kaçmaz, Keziban, Heinloth, Alexandra N., Simpson, Dennis A., Paules, Richard S., Sancar, Aziz, Cordeiro-Stone, Marila, Kaufmann, William K.
Publicat 2007

HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome

per Wardwell-Ozgo, Joanna, Dogruluk, Turgut, Gifford, Armel, Zhang, Yiqun, Heffernan, Timothy P., van Doorn, Remco, Creighton, Chad J., Chin, Lynda, Scott, Kenneth L.
Publicat 2013

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

per Lee, Michael S., Helms, Timothy L., Feng, Ningping, Gay, Jason, Chang, Qing Edward, Tian, Feng, Wu, Ji Y., Toniatti, Carlo, Heffernan, Timothy P., Powis, Garth, Kwong, Lawrence N., Kopetz, Scott
Publicat a Oncotarget (2016)

Caffeine and human DNA metabolism: the magic and the mystery

per Kaufmann, William K., Heffernan, Timothy P., Beaulieu, Lea M., Doherty, Sharon, Frank, Alexandra R., Zhou, Yingchun, Bryant, Miriam F., Zhou, Tong, Luche, Douglas D., Nikolaishvili-Feinberg, Nana, Simpson, Dennis A., Cordeiro-Stone, Marila
Publicat 2003

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

per Kawasumi, Masaoki, Lemos, Bianca, Bradner, James E., Thibodeau, Renee, Kim, Yong-son, Schmidt, Miranda, Higgins, Erin, Koo, Sang-wahn, Angle-Zahn, Aimee, Chen, Adam, Levine, Douglas, Nguyen, Lynh, Heffernan, Timothy P., Longo, Isabel, Mandinova, Anna, Lu, Yao-Ping, Conney, Allan H., Nghiem, Paul
Publicat 2011

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

per Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Publicat 2008

Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints

per Molkentine, Jessica M., Molkentine, David P., Bridges, Kathleen A., Xie, Tongxin, Yang, Liangpeng, Sheth, Aakash, Heffernan, Timothy P., Clump, David A., Faust, Alma Z., Ferris, Robert, Myers, Jeffrey N., Frederick, Mitchell J., Mason, Kathryn A., Meyn, Raymond E., Pickering, Curtis R., Skinner, Heath D.
Publicat a Int J Radiat Biol (2020)

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

per Peng, David H., Kundu, Samrat T., Fradette, Jared J., Diao, Lixia, Tong, Pan, Byers, Lauren A., Wang, Jing, Canales, Jaime Rodriguez, Villalobos, Pamela A., Mino, Barbara, Yang, Yanan, Minelli, Rosalba, Peoples, Michael D., Bristow, Christopher A., Heffernan, Timothy P., Carugo, Alessandro, Wistuba, Ignacio I., Gibbons, Don L.
Publicat a Sci Transl Med (2019)

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

per Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.
Publicat a Cell Stem Cell (2018)

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

per Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen
Publicat a Nat Commun (2018)

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

per Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
Publicat a Epigenetics Chromatin (2015)

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

per Powell, Emily, Shao, Jiansu, Picon, Hector M., Bristow, Christopher, Ge, Zhongqi, Peoples, Michael, Robinson, Frederick, Jeter-Jones, Sabrina L., Schlosberg, Christopher, Grzeskowiak, Caitlin L., Yang, Fei, Wu, Yun, Wistuba, Ignacio, Moulder, Stacy L., Symmans, William F., Scott, Kenneth L., Edwards, John R., Liang, Han, Heffernan, Timothy P., Piwnica-Worms, Helen
Publicat a NPJ Breast Cancer (2018)

Dual Roles of RNF2 in Melanoma Progression

per Rai, Kunal, Akdemir, Kadir C., Kwong, Lawrence N., Fiziev, Petko, Wu, Chang-Jiun, Keung, Emily Z., Sharma, Sneha, Samant, Neha S., Williams, Maura, Axelrad, Jacob B., Shah, Amiksha, Yang, Dong, Grimm, Elizabeth A., Barton, Michelle C., Milton, Denai R., Heffernan, Timothy P., Horner, James W., Ekmekcioglu, Suhendan, Lazar, Alexander, Ernst, Jason, Chin, Lynda
Publicat a Cancer Discov (2015)

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

per Tu, Bo, Yao, Jun, Ferri-Borgogno, Sammy, Zhao, Jun, Chen, Shujuan, Wang, Qiuyun, Yan, Liang, Zhou, Xin, Zhu, Cihui, Bang, Seungmin, Chang, Qing, Bristow, Christopher A., Kang, Ya’an, Zheng, Hongwu, Wang, Huamin, Fleming, Jason B., Kim, Michael, Heffernan, Timothy P., Draetta, Giulio F., Pan, Duojia, Maitra, Anirban, Yao, Wantong, Gupta, Sonal, Ying, Haoqiang
Publicat a JCI Insight (2019)

Pro-invasion metastasis drivers in early stage melanoma are oncogenes

per Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Woude, George Vande, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda
Publicat 2011