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Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G(1 )checkpoint function
BACKGROUND: Secondary cultures of human fibroblasts display a finite lifespan ending at senescence. Loss of p53 function by mutation or viral oncogene expression bypasses senescence, allowing cell division to continue for an additional 10 – 20 doublings. During this time chromosomal aberrations seen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1262734/ https://ncbi.nlm.nih.gov/pubmed/16209708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3163-4-18 |
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