An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Inhibition of replicon initiation is a stereotypic DNA damage response mediated through S checkpoint mechanisms not yet fully understood. Studies were undertaken to elucidate the function of checkpoint proteins in the inhibition of replicon initiation following irradiation with 254 nm UV light (UVC)...

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Detalhes bibliográficos
Main Authors: Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., Heinloth, Alexandra N., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139882/
https://ncbi.nlm.nih.gov/pubmed/12446774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8552-8561.2002
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