The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating stability and function of the protein. Because no known kinase has been identified that can modify this site, HeLa nuclear extracts were frac...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Shieh, Sheau-Yann, Ahn, Jinwoo, Tamai, Katsuyuki, Taya, Yoichi, Prives, Carol
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316358/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10673501/
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