p53 accumulates but is functionally impaired when DNA synthesis is blocked

p53 is required for the induction of a G(1) and/or G(2) irreversible arrest after γ irradiation (IR), whereas blocked DNA replication causes a p53-independent S-phase arrest. We have examined the response to p53 when DNA synthesis is blocked by hydroxyurea (HU) or aphidicolin or when DNA is damaged...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Gottifredi, Vanesa, Shieh, Sheau-Yann, Taya, Yoichi, Prives, Carol
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2001
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158590/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.021282898
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