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p53 accumulates but is functionally impaired when DNA synthesis is blocked
p53 is required for the induction of a G(1) and/or G(2) irreversible arrest after γ irradiation (IR), whereas blocked DNA replication causes a p53-independent S-phase arrest. We have examined the response to p53 when DNA synthesis is blocked by hydroxyurea (HU) or aphidicolin or when DNA is damaged...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC14704/ https://ncbi.nlm.nih.gov/pubmed/11158590 |
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