p53 accumulates but is functionally impaired when DNA synthesis is blocked
p53 is required for the induction of a G(1) and/or G(2) irreversible arrest after γ irradiation (IR), whereas blocked DNA replication causes a p53-independent S-phase arrest. We have examined the response to p53 when DNA synthesis is blocked by hydroxyurea (HU) or aphidicolin or when DNA is damaged...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2001
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158590/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.021282898 |
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