Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the phosphorylation of BRCA1 and causes its recruitment into nuclear foci that contain DNA repair proteins. The ataxia-...

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Main Authors: Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., Abraham, Robert T.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2000
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC317107/
https://ncbi.nlm.nih.gov/pubmed/11114888
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