Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the phosphorylation of BRCA1 and causes its recruitment into nuclear foci that contain DNA repair proteins. The ataxia-...

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Cyhoeddwyd yn:	Genes Dev
Prif Awduron:	Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., Abraham, Robert T.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Cold Spring Harbor Laboratory Press 2000
Pynciau:	Research Paper
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.851000
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