Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the phosphorylation of BRCA1 and causes its recruitment into nuclear foci that contain DNA repair proteins. The ataxia-...

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書誌詳細

出版年:	Genes Dev
主要な著者:	Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., Abraham, Robert T.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Cold Spring Harbor Laboratory Press 2000
主題:	Research Paper
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.851000
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