Aberrant cell cycle checkpoint function and early embryonic death in Chk1(−/−) mice

The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle. However, the function of Chk1 in mammals has re...

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Detalhes bibliográficos
Main Authors: Takai, Hiroyuki, Tominaga, Kaoru, Motoyama, Noboru, Minamishima, Yohji A., Nagahama, Hiroyasu, Tsukiyama, Tadasuke, Ikeda, Kyoji, Nakayama, Keiko, Nakanishi, Makoto, Nakayama, Kei-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316691/
https://ncbi.nlm.nih.gov/pubmed/10859163
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