Degradation of p57(Kip2) mediated by SCF(Skp2)-dependent ubiquitylation

The abundance of the cyclin-dependent kinase (CDK) inhibitor p57(Kip2), an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCF(Skp2) has now been shown to be responsible for reg...

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Detalhes bibliográficos
Main Authors: Kamura, Takumi, Hara, Taichi, Kotoshiba, Shuhei, Yada, Masayoshi, Ishida, Noriko, Imaki, Hiroyuki, Hatakeyama, Shigetsugu, Nakayama, Keiko, Nakayama, Keiichi I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193544/
https://ncbi.nlm.nih.gov/pubmed/12925736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1831009100
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