Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by proteolysis of its inhibitory subunit (IκB) via the ubiquitin-proteasome pathway. Signal-induced phosphorylation of IκBα by a large multisubunit complex containing IκB kinases is a prerequisite for ubiquitination....

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Detalhes bibliográficos
Main Authors: Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Shirane, Michiko, Matsumoto, Masaki, Hattori, Kimihiko, Higashi, Hideaki, Nakano, Hiroyasu, Okumura, Ko, Onoé, Kazunori, Good, Robert A., Nakayama, Kei-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22385/
https://ncbi.nlm.nih.gov/pubmed/10097128
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