Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by proteolysis of its inhibitory subunit (IκB) via the ubiquitin-proteasome pathway. Signal-induced phosphorylation of IκBα by a large multisubunit complex containing IκB kinases is a prerequisite for ubiquitination....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Shirane, Michiko, Matsumoto, Masaki, Hattori, Kimihiko, Higashi, Hideaki, Nakano, Hiroyasu, Okumura, Ko, Onoé, Kazunori, Good, Robert A., Nakayama, Kei-ichi
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 1999
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC22385/
https://ncbi.nlm.nih.gov/pubmed/10097128
תגים: הוספת תג
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