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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(−/−) mice

The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle. However, the function of Chk1 in mammals has re...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Genes Dev
Hauptverfasser: Takai, Hiroyuki, Tominaga, Kaoru, Motoyama, Noboru, Minamishima, Yohji A., Nagahama, Hiroyasu, Tsukiyama, Tadasuke, Ikeda, Kyoji, Nakayama, Keiko, Nakanishi, Makoto, Nakayama, Kei-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2000
Schlagworte:
Research Paper
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316691/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859163/
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