In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis

door Lechartier, Benoit, Hartkoorn, Ruben C., Cole, Stewart T.
Gepubliceerd in 2012

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

door Hartkoorn, Ruben C., Uplekar, Swapna, Cole, Stewart T.
Gepubliceerd in 2014

Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins

door Horlacher, Oliver P., Hartkoorn, Ruben C., Cole, Stewart T., Altmann, Karl-Heinz
Gepubliceerd in 2012

Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis

door Hartkoorn, Ruben C., Sala, Claudia, Uplekar, Swapna, Busso, Philippe, Rougemont, Jacques, Cole, Stewart T.
Gepubliceerd in 2012

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

door Zhang, Ming, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Mendoza-Losana, Alfonso, Cole, Stewart T.
Gepubliceerd in 2012

Sigma Factor F Does Not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis

door Hartkoorn, Ruben C., Sala, Claudia, Magnet, Sophie J., Chen, Jeffrey M., Pojer, Florence, Cole, Stewart T.
Gepubliceerd in 2010

Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis

door Hartkoorn, Ruben C., Ryabova, Olga B., Chiarelli, Laurent R., Riccardi, Giovanna, Makarov, Vadim, Cole, Stewart T.
Gepubliceerd in 2014

Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis

door Vocat, Anthony, Hartkoorn, Ruben C., Lechartier, Benoit, Zhang, Ming, Dhar, Neeraj, Cole, Stewart T., Sala, Claudia
Gepubliceerd in Antimicrob Agents Chemother (2015)

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides

door Ollivier, Nathalie, Toupy, Thomas, Hartkoorn, Ruben C., Desmet, Rémi, Monbaliu, Jean-Christophe M., Melnyk, Oleg
Gepubliceerd in Nat Commun (2018)

Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis

door Sala, Claudia, Dhar, Neeraj, Hartkoorn, Ruben C., Zhang, Ming, Ha, Young Hwan, Schneider, Patricia, Cole, Stewart T.
Gepubliceerd in 2010

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

door Hartkoorn, Ruben C, Sala, Claudia, Neres, João, Pojer, Florence, Magnet, Sophie, Mukherjee, Raju, Uplekar, Swapna, Boy-Röttger, Stefanie, Altmann, Karl-Heinz, Cole, Stewart T
Gepubliceerd in 2012

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

door Dogga, Sunil Kumar, Mukherjee, Budhaditya, Jacot, Damien, Kockmann, Tobias, Molino, Luca, Hammoudi, Pierre-Mehdi, Hartkoorn, Ruben C, Hehl, Adrian B, Soldati-Favre, Dominique
Gepubliceerd in eLife (2017)

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

door Makarov, Vadim, Neres, João, Hartkoorn, Ruben C., Ryabova, Olga B., Kazakova, Elena, Šarkan, Michal, Huszár, Stanislav, Piton, Jérémie, Kolly, Gaëlle S., Vocat, Anthony, Conroy, Trent M., Mikušová, Katarína, Cole, Stewart T.
Gepubliceerd in Antimicrob Agents Chemother (2015)

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

door Hartkoorn, Ruben C, San Kwan, Wai, Shallcross, Victoria, Chaikan, Ammara, Liptrott, Neill, Egan, Deirdre, Enrique Salcedo Sora, J, James, Chloe E, Gibbons, Sara, Bray, Pat G, Back, David J, Khoo, Saye H, Owen, Andrew
Gepubliceerd in Pharmacogenet Genomics (2010)

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

door Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C., Lingerfelt, Mary A., Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes
Gepubliceerd in PLoS One (2018)

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

door Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T
Gepubliceerd in 2014

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

door Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Gepubliceerd in ACS Infect Dis (2016)

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

door Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, de Jesus Lopes Ribeiro, Ana Luisa, Marino, Leonardo B., Centárová, Ivana, Svetlíková, Zuzana, Blaško, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikušová, Katarína, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T., Pasca, Maria Rosalia
Gepubliceerd in Chem Biol (2015)