Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis

Por Phetsuksiri, Benjawan, Baulard, Alain R., Cooper, Andrea M., Minnikin, David E., Douglas, James D., Besra, Gurdyal S., Brennan, Patrick J.
Publicado em 1999

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

Por Nikiforov, Petar O., Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R., Blundell, Tom L., Abell, Chris
Publicado no Org Biomol Chem (2016)

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Por Gurcha, Sudagar S, Baulard, Alain R, Kremer, Laurent, Locht, Camille, Moody, D Branch, Muhlecker, Walter, Costello, Catherine E, Crick, Dean C, Brennan, Patrick J, Besra, Gurdyal S
Publicado em 2002

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

Por Nikiforov, Petar O., Blaszczyk, Michal, Surade, Sachin, Boshoff, Helena I., Sajid, Andaleeb, Delorme, Vincent, Deboosere, Nathalie, Brodin, Priscille, Baulard, Alain R., Barry, Clifton E., Blundell, Tom L., Abell, Chris
Publicado no ACS Chem Biol (2017)

Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis()

Por Phetsuksiri, Benjawan, Jackson, Mary, Scherman, Hataichanok, McNeil, Michael, Besra, Gurdyal S., Baulard, Alain R., Slayden, Richard A., DeBarber, Andrea E., Barry, Clifton E., Baird, Mark S., Crick, Dean C., Brennan, Patrick J.
Publicado no J Biol Chem (2003)

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Por Carette, Xavier, Blondiaux, Nicolas, Willery, Eve, Hoos, Sylviane, Lecat-Guillet, Nathalie, Lens, Zoé, Wohlkönig, Alexandre, Wintjens, René, Soror, Sameh H., Frénois, Frédéric, Dirié, Bertrand, Villeret, Vincent, England, Patrick, Lippens, Guy, Deprez, Benoit, Locht, Camille, Willand, Nicolas, Baulard, Alain R.
Publicado em 2012

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Por Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, de Jesus Lopes Ribeiro, Ana Luisa, Marino, Leonardo B., Centárová, Ivana, Svetlíková, Zuzana, Blaško, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikušová, Katarína, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T., Pasca, Maria Rosalia
Publicado no Chem Biol (2015)