Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

Por Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S., Bugg, Timothy D.H.
Publicado em 2010

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

Por Usha, Veeraraghavan, Hobrath, Judith V., Gurcha, Sudagar S., Reynolds, Robert C., Besra, Gurdyal S.
Publicado em 2012

Modular Approach to Triazole-Linked 1,6-α-D-Oligomannosides to the Discovery of Inhibitors of Mycobacterium tuberculosis Cell Wall Synthetase

Por Conte, Mauro Lo, Marra, Alberto, Chambery, Angela, Gurcha, Sudagar S., Besra, Gurdyal S., Dondoni, Alessandro
Publicado em 2010

Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria

Por Rana, Amrita K., Singh, Albel, Gurcha, Sudagar S., Cox, Liam R., Bhatt, Apoorva, Besra, Gurdyal S.
Publicado em 2012

Disaccharide Analogs as Probes for Glycosyltransferases in Mycobacterium tuberculosis

Por Pathak, Ashish K., Pathak, Vibha, Seitz, Lainne, Gurcha, Sudagar S., Besra, Gurdyal S., Riordan, James M., Reynolds, Robert C.
Publicado em 2007

Synthesis of Symmetrical C- and Pseudo-symmetrical O-Linked Disaccharide Analogs for Arabinosyltransferase Inhibitory Activity in Mycobacterium tuberculosis

Por Pathak, Ashish K., Pathak, Vibha, Riordan, James R., Suling, William J., Gurcha, Sudagar S., Besra, Gurdyal S., Reynolds, Robert C.
Publicado em 2007

Synthesis of Deoxygenated (α 1→5)-Linked Arabinofuranose Disaccharides as Substrates and Inhibitors of Arabinosyltransferases of Mycobacterium tuberculosis

Por Pathak, Ashish K., Pathak, Vibha, Suling, William J., Riordan, James R., Gurcha, Sudagar S., Besra, Gurdyal S., Reynolds, Robert C.
Publicado em 2008

A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

Por Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., Besra, Gurdyal S., Coates, Anthony R. M.
Publicado em 2008

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Por Kremer, Laurent, Gurcha, Sudagar S, Bifani, Pablo, Hitchen, Paul G, Baulard, Alain, Morris, Howard R, Dell, Anne, Brennan, Patrick J, Besra, Gurdyal S
Publicado em 2002

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases

Por Guy, Mark R., Illarionov, Petr A., Gurcha, Sudagar S., Dover, Lynn G., Gibson, Kevin J. C., Smith, Paul W., Minnikin, David E., Besra, Gurdyal S.
Publicado em 2004

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice

Por Bhatt, Apoorva, Fujiwara, Nagatoshi, Bhatt, Kiranmai, Gurcha, Sudagar S., Kremer, Laurent, Chen, Bing, Chan, John, Porcelli, Steven A., Kobayashi, Kazuo, Besra, Gurdyal S., Jacobs, William R.
Publicado em 2007

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Por Dao, Dee N., Sweeney, Kari, Hsu, Tsungda, Gurcha, Sudagar S., Nascimento, Ivan P., Roshevsky, Dan, Besra, Gurdyal S., Chan, John, Porcelli, Steven A., Jacobs, William R.
Publicado em 2008

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant

Por Mishra, Arun K., Klein, Christina, Gurcha, Sudagar S., Alderwick, Luke J., Babu, Ponnusamy, Hitchen, Paul G., Morris, Howard R., Dell, Anne, Besra, Gurdyal S., Eggeling, Lothar
Publicado em 2008

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis

Por Sambandan, Dhinakaran, Dao, Dee N., Weinrick, Brian C., Vilchèze, Catherine, Gurcha, Sudagar S., Ojha, Anil, Kremer, Laurent, Besra, Gurdyal S., Hatfull, Graham F., Jacobs, William R.
Publicado em 2013

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Por Gurcha, Sudagar S, Baulard, Alain R, Kremer, Laurent, Locht, Camille, Moody, D Branch, Muhlecker, Walter, Costello, Catherine E, Crick, Dean C, Brennan, Patrick J, Besra, Gurdyal S
Publicado em 2002

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Por Ivanova, Irina M., Nepogodiev, Sergey A., Saalbach, Gerhard, O'Neill, Ellis C., Urbaniak, Michael D., Ferguson, Michael A.J., Gurcha, Sudagar S., Besra, Gurdyal S., Field, Robert A.
Publicado no Carbohydr Res (2017)

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

Por Kendall, Sharon L, Withers, Mike, Soffair, Catherine N, Moreland, Nicole J, Gurcha, Sudagar, Sidders, Ben, Frita, Rosangela, ten Bokum, Annemieke, Besra, Gurdyal S, Lott, J Shaun, Stoker, Neil G
Publicado em 2007

Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human...

Por Torrelles, Jordi B, DesJardin, Lucy E, MacNeil, Jessica, Kaufman, Thomas M, Kutzbach, Beth, Knaup, Rose, McCarthy, Travis R, Gurcha, Sudagar S, Besra, Gurdyal S, Clegg, Steven, Schlesinger, Larry S
Publicado em 2009

Role of Phosphatidylinositol Mannosides in the Interaction between Mycobacteria and DC-SIGN

Por Driessen, Nicole N., Ummels, Roy, Maaskant, Janneke J., Gurcha, Sudagar S., Besra, Gurdyal S., Ainge, Gary D., Larsen, David S., Painter, Gavin F., Vandenbroucke-Grauls, Christina M. J. E., Geurtsen, Jeroen, Appelmelk, Ben J.
Publicado em 2009

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

Por Stoop, Esther J. M., Schipper, Tim, Rosendahl Huber, Sietske K., Nezhinsky, Alexander E., Verbeek, Fons J., Gurcha, Sudagar S., Besra, Gurdyal S., Vandenbroucke-Grauls, Christina M. J. E., Bitter, Wilbert, van der Sar, Astrid M.
Publicado em 2011