A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival. A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism...

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Main Authors: Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., Besra, Gurdyal S., Coates, Anthony R. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292875/
https://ncbi.nlm.nih.gov/pubmed/18227175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01078-07
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