A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival. A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism...

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Bibliografiset tiedot
Päätekijät: Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., Besra, Gurdyal S., Coates, Anthony R. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2008
Aiheet:
Host Response and Inflammation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292875/
https://ncbi.nlm.nih.gov/pubmed/18227175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01078-07
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