A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival. A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism...

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Xehetasun bibliografikoak
Egile Nagusiak: Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., Besra, Gurdyal S., Coates, Anthony R. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2008
Gaiak:
Host Response and Inflammation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292875/
https://ncbi.nlm.nih.gov/pubmed/18227175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01078-07
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