A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection

The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival. A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., Besra, Gurdyal S., Coates, Anthony R. M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Host Response and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292875/
https://ncbi.nlm.nih.gov/pubmed/18227175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01078-07
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires