Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

[Image: see text] Small-molecule inhibitors of the mycobacterial transcriptional repressor EthR have previously been shown to act as boosters of the second-line antituberculosis drug ethionamide. Fragment-based drug discovery approaches have been used in the past to make highly potent EthR inhibitor...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Nikiforov, Petar O., Blaszczyk, Michal, Surade, Sachin, Boshoff, Helena I., Sajid, Andaleeb, Delorme, Vincent, Deboosere, Nathalie, Brodin, Priscille, Baulard, Alain R., Barry, Clifton E., Blundell, Tom L., Abell, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474694/
https://ncbi.nlm.nih.gov/pubmed/28314097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00091
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