In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis

par Lechartier, Benoit, Hartkoorn, Ruben C., Cole, Stewart T.
Publié 2012

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

par Hartkoorn, Ruben C., Uplekar, Swapna, Cole, Stewart T.
Publié 2014

Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins

par Horlacher, Oliver P., Hartkoorn, Ruben C., Cole, Stewart T., Altmann, Karl-Heinz
Publié 2012

Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis

par Hartkoorn, Ruben C., Sala, Claudia, Uplekar, Swapna, Busso, Philippe, Rougemont, Jacques, Cole, Stewart T.
Publié 2012

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

par Zhang, Ming, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Mendoza-Losana, Alfonso, Cole, Stewart T.
Publié 2012

Sigma Factor F Does Not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis

par Hartkoorn, Ruben C., Sala, Claudia, Magnet, Sophie J., Chen, Jeffrey M., Pojer, Florence, Cole, Stewart T.
Publié 2010

Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis

par Hartkoorn, Ruben C., Ryabova, Olga B., Chiarelli, Laurent R., Riccardi, Giovanna, Makarov, Vadim, Cole, Stewart T.
Publié 2014

Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis

par Vocat, Anthony, Hartkoorn, Ruben C., Lechartier, Benoit, Zhang, Ming, Dhar, Neeraj, Cole, Stewart T., Sala, Claudia
Publié dans Antimicrob Agents Chemother (2015)

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides

par Ollivier, Nathalie, Toupy, Thomas, Hartkoorn, Ruben C., Desmet, Rémi, Monbaliu, Jean-Christophe M., Melnyk, Oleg
Publié dans Nat Commun (2018)

Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis

par Sala, Claudia, Dhar, Neeraj, Hartkoorn, Ruben C., Zhang, Ming, Ha, Young Hwan, Schneider, Patricia, Cole, Stewart T.
Publié 2010

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

par Hartkoorn, Ruben C, Sala, Claudia, Neres, João, Pojer, Florence, Magnet, Sophie, Mukherjee, Raju, Uplekar, Swapna, Boy-Röttger, Stefanie, Altmann, Karl-Heinz, Cole, Stewart T
Publié 2012

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

par Dogga, Sunil Kumar, Mukherjee, Budhaditya, Jacot, Damien, Kockmann, Tobias, Molino, Luca, Hammoudi, Pierre-Mehdi, Hartkoorn, Ruben C, Hehl, Adrian B, Soldati-Favre, Dominique
Publié dans eLife (2017)

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

par Makarov, Vadim, Neres, João, Hartkoorn, Ruben C., Ryabova, Olga B., Kazakova, Elena, Šarkan, Michal, Huszár, Stanislav, Piton, Jérémie, Kolly, Gaëlle S., Vocat, Anthony, Conroy, Trent M., Mikušová, Katarína, Cole, Stewart T.
Publié dans Antimicrob Agents Chemother (2015)

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

par Hartkoorn, Ruben C, San Kwan, Wai, Shallcross, Victoria, Chaikan, Ammara, Liptrott, Neill, Egan, Deirdre, Enrique Salcedo Sora, J, James, Chloe E, Gibbons, Sara, Bray, Pat G, Back, David J, Khoo, Saye H, Owen, Andrew
Publié dans Pharmacogenet Genomics (2010)

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

par Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C., Lingerfelt, Mary A., Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes
Publié dans PLoS One (2018)

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

par Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T
Publié 2014

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

par Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Publié dans ACS Infect Dis (2016)

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

par Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, de Jesus Lopes Ribeiro, Ana Luisa, Marino, Leonardo B., Centárová, Ivana, Svetlíková, Zuzana, Blaško, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikušová, Katarína, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T., Pasca, Maria Rosalia
Publié dans Chem Biol (2015)