A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis

Por Knudson, Susan E., Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélèn, Ojima, Iwao, Slayden, Richard A.
Publicado em 2014

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model

Por Knudson, Susan E., Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélène, Ojima, Iwao, Slayden, Richard A.
Publicado no J Antimicrob Chemother (2015)

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

Por Huszár, Stanislav, Singh, Vinayak, Polčicová, Alica, Baráth, Peter, Barrio, María Belén, Lagrange, Sophie, Leblanc, Véronique, Nacy, Carol A., Mizrahi, Valerie, Mikušová, Katarína
Publicado no Antimicrob Agents Chemother (2017)

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Por Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Publicado no ACS Infect Dis (2016)

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

Por Lopez Quezada, Landys, Silve, Sandra, Kelinske, Mark, Liba, Amir, Diaz Gonzalez, Constantino, Kotev, Martin, Goullieux, Laurent, Sans, Stephanie, Roubert, Christine, Lagrange, Sophie, Bacqué, Eric, Couturier, Cedric, Pellet, Alain, Blanc, Isabelle, Ferron, Marlène, Debu, Fabrice, Li, Kelin, Aubé, Jeffrey, Roberts, Julia, Little, David, Ling, Yan, Zhang, Jun, Gold, Ben, Nathan, Carl
Publicado no mBio (2019)

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

Por Ballinger, Elaine, Mosior, John, Hartman, Travis, Burns-Huang, Kristin, Gold, Ben, Morris, Roxanne, Goullieux, Laurent, Blanc, Isabelle, Vaubourgeix, Julien, Lagrange, Sophie, Fraisse, Laurent, Sans, Stéphanie, Couturier, Cedric, Bacqué, Eric, Rhee, Kyu, Scarry, Sarah M., Aubé, Jeffrey, Yang, Guangbin, Ouerfelli, Ouathek, Schnappinger, Dirk, Ioerger, Thomas R., Engelhart, Curtis A., McConnell, Jennifer A., McAulay, Kathrine, Fay, Allison, Roubert, Christine, Sacchettini, James, Nathan, Carl
Publicado no Science (2019)

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis

Por Qpezada, Landys Lopez, Li, Kelin, McDonald, Stacey L., Nguyen, Quyen, Perkowski, Andrew J., Pharr, Cameron W., Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Karakaya, Selin Somersan, Javidnia, Prisca Elis, de Francisco, Esther Porras, Amieva, Manuel Marin, Díaz, Sara Palomo, Losana, Alfonso Mendoza, Zimmerman, Matthew, Ho Liang, Hsin-Pin, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey
Publicado no ACS Infect Dis (2019)