N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

The mycobacterial phosphoglycosyltransferase WecA, which initiates arabinogalactan biosynthesis in Mycobacterium tuberculosis, has been proposed as a target of the caprazamycin derivative CPZEN-45, a preclinical drug candidate for the treatment of tuberculosis. In this report, we describe the functi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Huszár, Stanislav, Singh, Vinayak, Polčicová, Alica, Baráth, Peter, Barrio, María Belén, Lagrange, Sophie, Leblanc, Véronique, Nacy, Carol A., Mizrahi, Valerie, Mikušová, Katarína
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655080/
https://ncbi.nlm.nih.gov/pubmed/28874370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01310-17
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