Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45

Because tuberculosis is one of the most prevalent and serious infections, countermeasures against it are urgently required. We isolated the antitubercular agents caprazamycins from the culture of an actinomycete strain and created CPZEN-45 as the most promising derivative of the caprazamycins. Herei...

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Bibliographic Details
Main Authors: Ishizaki, Yoshimasa, Hayashi, Chigusa, Inoue, Kunio, Igarashi, Masayuki, Takahashi, Yoshiaki, Pujari, Venugopal, Crick, Dean C., Brennan, Patrick J., Nomoto, Akio
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798496/
https://ncbi.nlm.nih.gov/pubmed/23986448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492173
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