Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model

OBJECTIVES: The increasing number of clinical strains resistant to one or more of the front-line TB drugs complicates the management of this disease. To develop next-generation benzimidazole-based FtsZ inhibitors with improved efficacy, we employed iterative optimization strategies based on whole ba...

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Bibliografische gegevens
Gepubliceerd in:J Antimicrob Chemother
Hoofdauteurs: Knudson, Susan E., Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélène, Ojima, Iwao, Slayden, Richard A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613742/
https://ncbi.nlm.nih.gov/pubmed/26245639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv226
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