Engineering of Helicobacter pylori L-Asparaginase: Characterization of Two Functionally Distinct Groups of Mutants

af Maggi, Maristella, Chiarelli, Laurent R., Valentini, Giovanna, Scotti, Claudia
Udgivet i PLoS One (2015)

Tackling Critical Catalytic Residues in Helicobacter pylori l-Asparaginase

af Maggi, Maristella, Chiarelli, Laurent R, Valentini, Giovanna, Scotti, Claudia
Udgivet i Biomolecules (2015)

Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens

af Scoffone, Viola Camilla, Trespidi, Gabriele, Chiarelli, Laurent R., Barbieri, Giulia, Buroni, Silvia
Udgivet i Int J Mol Sci (2019)

Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor Malignancy

af Rognoni, Paola, Chiarelli, Laurent R., Comincini, Sergio, Azzalin, Alberto, Miracco, Clelia, Valentini, Giovanna
Udgivet 2010

Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches

af Scoffone, Viola C., Chiarelli, Laurent R., Trespidi, Gabriele, Mentasti, Massimo, Riccardi, Giovanna, Buroni, Silvia
Udgivet i Front Microbiol (2017)

Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis

af Hartkoorn, Ruben C., Ryabova, Olga B., Chiarelli, Laurent R., Riccardi, Giovanna, Makarov, Vadim, Cole, Stewart T.
Udgivet 2014

Molecular Insights on Pathogenic Effects of Mutations Causing Phosphoglycerate Kinase Deficiency

af Chiarelli, Laurent R., Morera, Simone M., Bianchi, Paola, Fermo, Elisa, Zanella, Alberto, Galizzi, Alessandro, Valentini, Giovanna
Udgivet 2012

Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy

af Chiarelli, Laurent R, Molinaro, Mariadelfina, Libetta, Carmelo, Tinelli, Carmine, Cosmai, Laura, Valentini, Giovanna, Canton, Antonio Dal, Regazzi, Mario
Udgivet 2010

Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

af Lucarelli, Anna P., Buroni, Silvia, Pasca, Maria R., Rizzi, Menico, Cavagnino, Andrea, Valentini, Giovanna, Riccardi, Giovanna, Chiarelli, Laurent R.
Udgivet 2010

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

af Mori, Matteo, Stelitano, Giovanni, Chiarelli, Laurent R., Cazzaniga, Giulia, Gelain, Arianna, Barlocco, Daniela, Pini, Elena, Meneghetti, Fiorella, Villa, Stefania
Udgivet i Pharmaceuticals (Basel) (2021)

Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug

af Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent R., Degiacomi, Giulia, Riabova, Olga, Sammartino, José Camilla, Makarov, Vadim, Riccardi, Giovanna, Pasca, Maria Rosalia
Udgivet i Front Microbiol (2020)

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

af Buroni, Silvia, Scoffone, Viola C., Fumagalli, Marco, Makarov, Vadim, Cagnone, Maddalena, Trespidi, Gabriele, De Rossi, Edda, Forneris, Federico, Riccardi, Giovanna, Chiarelli, Laurent R.
Udgivet i Front Pharmacol (2018)

Phenylacetyl Coenzyme A, Not Phenylacetic Acid, Attenuates CepIR-Regulated Virulence in Burkholderia cenocepacia

af Lightly, Tasia Joy, Frejuk, Kara L., Groleau, Marie-Christine, Chiarelli, Laurent R., Ras, Cor, Buroni, Silvia, Déziel, Eric, Sorensen, John L., Cardona, Silvia T.
Udgivet i Appl Environ Microbiol (2019)

Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia

af Chiarelli, Laurent R., Scoffone, Viola Camilla, Trespidi, Gabriele, Barbieri, Giulia, Riabova, Olga, Monakhova, Natalia, Porta, Alessio, Manina, Giulia, Riccardi, Giovanna, Makarov, Vadim, Buroni, Silvia
Udgivet i Front Microbiol (2020)

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

af Scoffone, Viola C., Chiarelli, Laurent R., Makarov, Vadim, Brackman, Gilles, Israyilova, Aygun, Azzalin, Alberto, Forneris, Federico, Riabova, Olga, Savina, Svetlana, Coenye, Tom, Riccardi, Giovanna, Buroni, Silvia
Udgivet i Sci Rep (2016)

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043

af Tiwari, Rohit, Miller, Patricia A., Chiarelli, Laurent R., Mori, Giorgia, Šarkan, Michal, Centárová, Ivana, Cho, Sanghyun, Mikušová, Katarína, Franzblau, Scott G., Oliver, Allen G., Miller, Marvin J.
Udgivet i ACS Med Chem Lett (2016)

Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

af Sass, Andrea, Slachmuylders, Lisa, Van Acker, Heleen, Vandenbussche, Ian, Ostyn, Lisa, Bové, Mona, Crabbé, Aurélie, Chiarelli, Laurent R., Buroni, Silvia, Van Nieuwerburgh, Filip, Abatih, Emmanuel, Coenye, Tom
Udgivet i Antimicrob Agents Chemother (2019)

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

af Mori, Matteo, Stelitano, Giovanni, Gelain, Arianna, Pini, Elena, Chiarelli, Laurent R., Sammartino, José C., Poli, Giulio, Tuccinardi, Tiziano, Beretta, Giangiacomo, Porta, Alessio, Bellinzoni, Marco, Villa, Stefania, Meneghetti, Fiorella
Udgivet i J Med Chem (2020)

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053

af Albesa-Jové, David, Comino, Natalia, Tersa, Montse, Mohorko, Elisabeth, Urresti, Saioa, Dainese, Elisa, Chiarelli, Laurent R., Pasca, Maria Rosalia, Manganelli, Riccardo, Makarov, Vadim, Riccardi, Giovanna, Svergun, Dmitri I., Glockshuber, Rudi, Guerin, Marcelo E.
Udgivet i J Biol Chem (2015)

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

af Chiarelli, Laurent R., Mori, Matteo, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Sammartino, Josè Camilla, Stelitano, Giovanni, Barlocco, Daniela, Costantino, Luca, Lapillo, Margherita, Poli, Giulio, Caligiuri, Isabella, Rizzolio, Flavio, Bellinzoni, Marco, Tuccinardi, Tiziano, Villa, Stefania, Meneghetti, Fiorella
Udgivet i J Enzyme Inhib Med Chem (2019)