Phenylacetyl Coenzyme A, Not Phenylacetic Acid, Attenuates CepIR-Regulated Virulence in Burkholderia cenocepacia

During phenylalanine catabolism, phenylacetic acid (PAA) is converted to phenylacetyl coenzyme A (PAA-CoA) by a ligase, PaaK, and then PAA-CoA is epoxidized by a multicomponent monooxygenase, PaaABCDE, before further degradation through the tricarboxylic acid (TCA) cycle. In the opportunistic pathog...

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Udgivet i:Appl Environ Microbiol
Main Authors: Lightly, Tasia Joy, Frejuk, Kara L., Groleau, Marie-Christine, Chiarelli, Laurent R., Ras, Cor, Buroni, Silvia, Déziel, Eric, Sorensen, John L., Cardona, Silvia T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881814/
https://ncbi.nlm.nih.gov/pubmed/31585996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01594-19
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