Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

Quorum sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases, siderophores, and toxins, as well as biofilm formation. Since the inhibition of this pathway reduces bacterial virulence, QS is considered a valuable ca...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Buroni, Silvia, Scoffone, Viola C., Fumagalli, Marco, Makarov, Vadim, Cagnone, Maddalena, Trespidi, Gabriele, De Rossi, Edda, Forneris, Federico, Riccardi, Giovanna, Chiarelli, Laurent R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079302/
https://ncbi.nlm.nih.gov/pubmed/30108505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00836
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