Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

Quorum sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases, siderophores, and toxins, as well as biofilm formation. Since the inhibition of this pathway reduces bacterial virulence, QS is considered a valuable ca...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Buroni, Silvia, Scoffone, Viola C., Fumagalli, Marco, Makarov, Vadim, Cagnone, Maddalena, Trespidi, Gabriele, De Rossi, Edda, Forneris, Federico, Riccardi, Giovanna, Chiarelli, Laurent R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079302/
https://ncbi.nlm.nih.gov/pubmed/30108505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00836
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