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Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis
On using the streptomycin-starved 18b strain as a model for nonreplicating Mycobacterium tuberculosis, we identified a 5-nitrothiophene compound as highly active but not cytotoxic. Mutants resistant to 5-nitrothiophenes were found be cross-resistant to the nitroimidazole PA-824 and unable to produce...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993272/ https://ncbi.nlm.nih.gov/pubmed/24550336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02693-13 |
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