Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy

AIMS: Long-term mycophenolate mofetil (MMF) therapy may induce inosine 5′-monophosphate dehydrogenase (IMPDH) activity in peripheral blood mononuclear cells (PBMCs), thus decreasing MMF immunosuppressive properties. Pharmacodynamic monitoring was used to investigate whether biological activity is al...

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Detalhes bibliográficos
Main Authors: Chiarelli, Laurent R, Molinaro, Mariadelfina, Libetta, Carmelo, Tinelli, Carmine, Cosmai, Laura, Valentini, Giovanna, Canton, Antonio Dal, Regazzi, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830596/
https://ncbi.nlm.nih.gov/pubmed/20078611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03542.x
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