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Tackling Critical Catalytic Residues in Helicobacter pylori l-Asparaginase
Bacterial asparaginases (amidohydrolases, EC 3.5.1.1) are important enzymes in cancer therapy, especially for Acute Lymphoblastic Leukemia. They are tetrameric enzymes able to catalyze the deamination of l-ASN and, to a variable extent, of l-GLN, on which leukemia cells are dependent for survival. I...
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| Publicado no: | Biomolecules |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4496674/ https://ncbi.nlm.nih.gov/pubmed/25826146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom5020306 |
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