Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis

Isoxyl (ISO), a thiourea (thiocarlide; 4,4′-diisoamyloxythiocarbanilide), demonstrated potent activity against Mycobacterium tuberculosis H37Rv (MIC, 2.5 μg/ml), Mycobacterium bovis BCG (MIC, 0.5 μg/ml), Mycobacterium avium (MIC, 2.0 μg/ml), and Mycobacterium aurum A+ (MIC, 2.0 μg/ml), resulting in...

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Autors principals: Phetsuksiri, Benjawan, Baulard, Alain R., Cooper, Andrea M., Minnikin, David E., Douglas, James D., Besra, Gurdyal S., Brennan, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89109/
https://ncbi.nlm.nih.gov/pubmed/10223912
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