Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis

Isoxyl (ISO), a thiourea (thiocarlide; 4,4′-diisoamyloxythiocarbanilide), demonstrated potent activity against Mycobacterium tuberculosis H37Rv (MIC, 2.5 μg/ml), Mycobacterium bovis BCG (MIC, 0.5 μg/ml), Mycobacterium avium (MIC, 2.0 μg/ml), and Mycobacterium aurum A+ (MIC, 2.0 μg/ml), resulting in...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Phetsuksiri, Benjawan, Baulard, Alain R., Cooper, Andrea M., Minnikin, David E., Douglas, James D., Besra, Gurdyal S., Brennan, Patrick J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Mechanisms of Action: Physiological Effects
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89109/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1042
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