Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis()

The thiourea isoxyl (thiocarlide; 4,4′-diisoamyloxydiphenylthiourea) is known to be an effective anti-tuberculosis drug, active against a range of multidrug-resistant strains of Mycobacterium tuberculosis and has been used clinically. Little was known of its mode of action. We now demonstrate that i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Phetsuksiri, Benjawan, Jackson, Mary, Scherman, Hataichanok, McNeil, Michael, Besra, Gurdyal S., Baulard, Alain R., Slayden, Richard A., DeBarber, Andrea E., Barry, Clifton E., Baird, Mark S., Crick, Dean C., Brennan, Patrick J.
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747054/
https://ncbi.nlm.nih.gov/pubmed/14559907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M311209200
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