Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

[Image: see text] Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs formerly used in the clinical treatment of tuberculosis. Although both prodrugs have recently been shown to kill Mycobacterium tuberculosis through the inhibition of the dehydration step of the type II fatty acid s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Grzegorzewicz, Anna E., Eynard, Nathalie, Quémard, Annaïk, North, E. Jeffrey, Margolis, Alyssa, Lindenberger, Jared J., Jones, Victoria, Korduláková, Jana, Brennan, Patrick J., Lee, Richard E., Ronning, Donald R., McNeil, Michael R., Jackson, Mary
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401429/
https://ncbi.nlm.nih.gov/pubmed/25897434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500032q
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge