Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

[Image: see text] Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs formerly used in the clinical treatment of tuberculosis. Although both prodrugs have recently been shown to kill Mycobacterium tuberculosis through the inhibition of the dehydration step of the type II fatty acid s...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Infect Dis
मुख्य लेखकों: Grzegorzewicz, Anna E., Eynard, Nathalie, Quémard, Annaïk, North, E. Jeffrey, Margolis, Alyssa, Lindenberger, Jared J., Jones, Victoria, Korduláková, Jana, Brennan, Patrick J., Lee, Richard E., Ronning, Donald R., McNeil, Michael R., Jackson, Mary
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2014
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401429/
https://ncbi.nlm.nih.gov/pubmed/25897434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500032q
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