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Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis

Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitor...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Korduláková, Jana, Janin, Yves L., Liav, Avraham, Barilone, Nathalie, Dos Vultos, Tiago, Rauzier, Jean, Brennan, Patrick J., Gicquel, Brigitte, Jackson, Mary
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology (ASM) 2007
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151411/
https://ncbi.nlm.nih.gov/pubmed/17785510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00433-07
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