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Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis
Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitor...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151411/ https://ncbi.nlm.nih.gov/pubmed/17785510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00433-07 |
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