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Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis
Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitor...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151411/ https://ncbi.nlm.nih.gov/pubmed/17785510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00433-07 |
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